Events & News
D. Barrasso and R. Ramachandran. Qualitative assessment of a multi-scale, compartmental PBM-DEM model of a continuous twin-screw wet granulation process. Journal of Pharmaceutical Innovation, 1-19, 2015.
R. Singh, A. Roman, R. Romanach, M. Ierapetritou, R. Ramachandran. Real time monitoring of blend density for coupled feed-forward/feed-back control of a continuous direct compaction tablet manufacturing process. International Journal of Pharmaceutics, 495, 612-625, 2015.
R. Singh, F. Muzzio, M. Ierapetritou, R. Ramachandran. A combined feed-forward/feed-back control system for a QbD based continuous tablet manufacturing process. Processes, 3(2), 339-356, 2015.
R. Singh, F.J. Muzzio, M. G. Ierapetritou, R. Ramachandran. Plant-wide control of a continuous tablet manufacturing process for Quality-by-Design based pharmaceutical manufacturing. Computer Aided Chemical Engineering, 37, 2183-2188, 2015.
R. Singh, M. Sen, M. Ierapetritou, R. Ramachandran. Integrated moving horizon based real time optimization and hybrid MPC-PID control of a direct compaction continuous tablet manufacturing process. Journal of Pharmaceutical Innovation, 1-21, 2015.
D. Barrasso, A. Tamrakar, R. Ramachandran. Model order reduction of a multi-scale PBM-DEM description of a wet granulation process via ANN. Procedia Engineering, 102, 1295-1304, 2015.
S. Oka, H Emady, O. Kaspar, V. Tokarova, F. Muzzio, F. Stepanek, R. Ramachandran. The effects of improper mixing and preferential wetting of active and excipient ingredients on content uniformity in high shear wet granulation. Powder Technology, 266-277, 2015.
S. Oka, O. Kaspar, V. Tokarova, K. Sowrirajan, H. Wu, M. Khan, F. Muzzio, F. Stepanek, R. Ramachandran. A quantitative study of the effect of process parameters on key granule characteristics in a high shear wet granulation process. Advanced Powder Technology, 26(1), 315-322, 2015.
A. Chaudhury, A. Tamrakar, M. Schongut, D. Smrcka, F. Stepanek, R. Ramachandran. Multi-dimensional population balance model development and validation of reactive granulation processes.Industrial & Engineering Chemistry Research , 54 (3), 842-857, 2015.
D. Barrasso, T. Eppinger, F. Perera, R. Aglave, K. Debus, S. Bermingham, R. Ramachandran. A multi-scale, mechanistic model of a wet granulation process using a novel bi-directional PBM-DEM coupling algorithm.Chemical Engineering Science, 123, 500-513, 2015.
M. Ghodbane, A. Kulesa, H.H. Yu, T.J. Maguire, R.R. Schloss, R. Ramachandran, J.D. Zahn, and M.L. Yarmush, Development of a Low Volume, Highly Sensitive Microimmunoassay using Computational Fluid Dynamics Driven Multi-Objective Optimization, ,Microfluidics and Nanofluidics, 18 (2), 199-214, 2015.
D. Barrasso, A. El Hagrasy, J.D. Litster, R. Ramachandran. Multi-dimensional population balance model development and validation for a twin screw granulation process, Powder Technology, 270 B, 612-621, 2015.
D. Barrasso, R. Ramachandran. Multi-scale modeling of granulation processes: Bi-directional coupling of PBM with DEM via collision frequencies. Chemical Engineering Research & Design, 93, 304-317, 2015.
M. O. Besenhard, A. Chaudhury, T. Vetter, R. Ramachandran, J. Khinast. Evaluation of parameter estimation methods for crystallization processes modeled via population balance equations. Chemical Engineering Research & Design, 94, 275-289, 2015.
A. Chaudhury, M. E. Armenante and R. Ramachandran. Compartment based population balance modeling of a high shear wet granulation process using data analytics. Chemical Engineering Research & Design, 95, 211-228, 2015.