Experimental Studies & Analyses of
Here, we are working to understand the effect of granulation process parameters on granule content uniformity and dissolution and its subsequent effect on tablet properties (microstructure and dissolution). We are aiming to decouple the effects of segregation, preferential wetting and drug migration to be able to design and engineer optimal granules to influence and obtain quality tablets with desired properties.
Effect of Improper mixing: Visualization of pores in control volume
NIR Monitoring of Mulling Processes: 15 mm different distance spectra from 9 -21 mm with 1.5 mm interval
Micro-CT Study of Dissolution: Evolution of the dissolution front in sample during 24 hrs (the arrows indicate the initial positions of several large API crystals)
List of Publications from this Research Area:
S. Wu, S. Panikar, J. Zhang, R. Singh, B. Glasser, R. Ramachandran. A systematic framework to monitor mulling processes using Near Infrared spectroscopy. Advanced Powder Technology, Accepted, 2016.
M. Adepu, S. Hate, A. Betard, S. Oka, M. Schongut, Y. Sood, F. Stepanek, F. Muzzio, D. Wolf, S. Wieland, B. Glasser, R. Ramachandran. Quantitative validation of the regime map approach for the wet granulation of industrially relevant zirconium hydroxide powders. Powder Technology, vol, 177-184, 2016.
S. Oka, H Emady, O. Kaspar, V. Tokarova, F. Muzzio, F. Stepanek, R. Ramachandran. The effects of improper mixing and preferential wetting of active and excipient ingredients on content uniformity in high shear wet granulation. Powder Technology, 266-277, 2015.
S. Oka, O. Kaspar, V. Tokarova, K. Sowrirajan, H. Wu, M. Khan, F. Muzzio, F. Stepanek, R. Ramachandran. A quantitative study of the effect of process parameters on key granule characteristics in a high shear wet granulation process. Advanced Powder Technology, 26(1), 315-322, 2015.
J. Zhang, Y. Ying, B. Pielecha-Safira, E. Bilgili, R. Ramachandran, R. Rodolfo, R. Dave, Z. Iqbal. Raman spectroscopy for in-line and off-line quantification of poorly soluble drugs in strip films. International Journal of Pharmaceutics, 475 (1-2):428-437, 2014.